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Inventi Impact: Molecular Pharmacology

Articles

  • Inventi:pmp/19054/16
    Can Chronic Nitric Oxide Inhibition Improve Liver and Renal Dysfunction in Bile Duct Ligated Rats?
    01-Jan-1970 Research 2016 : April - June
    Mona Fouad Mahmoud, Sara Zakaria, Ahmed Fahmy

    The aims of the present work were to study the effects of chronic NO inhibition on liver cirrhosis and to analyze its relationship\nwith liver and kidney damage markers. Two inhibitors of NO synthesis (inducible NO synthase (iNOS) inhibitor, aminoguanidine\n(AG), and nonselective NOS inhibitor, L-nitroarginine methyl ester (L-NAME)) were administered for 6 weeks to bile duct ligated\n(BDL) rats 3 days after surgery. The present study showed that BDL was associated with liver injury and renal impairment. BDL\nincreased liver NO content and myeloperoxidase (MPO) activity. This was corroborated by increased oxidative stress, TNF-

    How to Cite this Article
    CC Compliant Citation: Mona Fouad Mahmoud, Sara Zakaria, and\nAhmed Fahmy, â??Can Chronic Nitric Oxide Inhibition Improve\nLiver and Renal Dysfunction in Bile Duct Ligated Rats?,â?\nAdvances in Pharmacological Sciences, vol. 2015, Article ID\n298792, 7 pages, 2015. doi:10.1155/2015/298792, http://\ncreativecommons.org/licenses/by/4.0/.
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